Evaluation and comparison of antimicrobial effect of graphene oxide and common antibiotics on standard and hospital Resistant Staphylococcus aureus

Background: Graphene chips are insoluble forms of graphene. Graphene is highly reactive and has no biocompatibility, but after oxidation, it becomes water-soluble. Graphene oxide (GO) is applied in biomedical, including gene and drug transfer, biomedical imaging, biomedical sensors, and antibiotics. Staphylococcus aureus is a gram-positive bacteria and is the most important species in Staphylococcus genus. Regarding the resistance of bacteria, biocompatible materials as antibiotics are important. The purpose of this study was to evaluate the antimicrobial properties of GO nanoparticles on Staphylococcus aureus. Methods: GO was produced using Homer method. In this study, after bacterial culture (hospital and standard), antimicrobial effect of GO alone and with conventional antibiotics, halo diameter test, and spectroscopy method was measured. MBC and MIC were used to measure the effects of different specimens Results: The results of this experiments showed that the GO decreased bacterial growth. Also, the results of treatment with GO and antibiotics showed a synergic effect. Statistical analysis of data obtained from synergism of erythromycin and gentamicin antibiotics was significant. Conclusion: Due to the resistance of bacteria, the production of new antimicrobial agents has always been considered. Since GO improves the inhibitory effect of antibiotics and given that the cost of its production is relatively economical, it seems that graphene oxide can be used as a new drug compounds.